Document Number: 20050042754
Abstract:
The present invention provides a method of inducing the formation of insulin-producing cells which comprises transferring a pancreatic β-cell associated transcriptional factor gene into the pancreas to induce the formation of insulin-producing cells. The pancreatic β-cell associated transcriptional factor gene is transferred into the pancreatic tissue stem cells by the ICBD injection without ligating the common bile ducts and thus the formation of insulin-producing cells is induced. In the present invention, pdx-1, neurogenin3, etc. are used as such pancreatic β-cell associated transcriptional factor gene and an adenoviral vector with the use of the Cre-loxP recombination system, etc. is used as a vector for transferring the pancreatic β-cell associated transcriptional factor gene into the pancreas. The method of the invention enables regeneration therapy for diabetes mellitus by inducing the formation of insulin-producing cells.
Application Number: 10877706
Primary Class: 435455000
Sub-Classes: 435366000
Inventors: Jun-ichi Miyazaki, Osaka, JP; Eiji Yamato, Osaka, JP; Fumi Tashiro, Osaka, JP; Hidenori Taniguchi, Osaka, JP
Attorney, Agent or Firm: FROMMER LAWRENCE & HAUG, 745 FIFTH AVENUE- 10TH FL., NEW YORK, NY, 10151, US
Priority: JP: 2001-399251, 2001-12-28
Continuation: US PCT/JP02/13684 (parent); US 10877706 (child)
Filing Date: 2004-06-25
Publication Date: 2005-02-24
PDF: 20050042754
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