BioPatents

Document Number: 20050042180

Abstract:

A powder inhalant for pulmonary or nasal inhalation, containing the CGRP antagonist 1-[N²-[3,5-dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazine (A) in the form of spherically nanostructured microparticles, which are stable in their amorphous state under normal conditions (T<50° C., relative humidity <75%), a process for preparing these microparticles as well as the use thereof for preparing the powder inhalant for the treatment of headaches, migraine and cluster headache.

Application Number: 10909624

Primary Class: 424046000

Sub-Classes: 514019000, 514252170

Inventors: Michael Trunk, Ingelheim, DE; Claudius Weiler, Ingelheim-Grosswinterheim, DE; Christel Schmelzer, Ingelheim, DE

Assignee: Boehringer Ingelheim International GmbH, Ingelheim, DE

Attorney, Agent or Firm: MICHAEL P. MORRIS;BOEHRINGER INGELHEIM CORPORATION, 900 RIDGEBURY ROAD, RIDGEFIELD, CT, 06877-0368, US

Priority: DE: 103 38 403, 2003-08-18

Provisional Application: US 60503015, 2003-09-15

Filing Date: 2004-08-02

Publication Date: 2005-02-24

PDF: 20050042180

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