Document Number: 20090055975
Abstract:
Provided is a peptide, peptide multimer or fusion protein containing such peptide which binds to the gut of sap-sucking insects, e.g., aphids. When bound, this peptide inhibits the binding of targeted virus to the insect gut. When this peptide or tandem repeat peptide is expressed (or is expressed as part of a fusion protein) in the fluids of transgenic plants, it is taken up by the insect with the sap, binds to gut receptors and thereby inhibits transmission of the virus from plant to plant via the insect vector. Thus, the use of such transgenic plants blocks or reduces the transmission of the targeted virus and others which share the peptide binding site within the insect gut among plants susceptible to the virus and thereby reduces losses due to viral infection.
Application Number: 12001776
Primary Class: 800298
Sub-Classes: 530327, 536 231, 536 234, 514 14
Inventors: Bryony Bonning, Ames, IA, US; W. Allen Miller, Ames, IA, US; Sijun Liu, Ames, IA, US
Assignee: Iowa State University Research Foundation, Inc., Ames, US
Attorney, Agent or Firm: GREENLEE WINNER AND SULLIVAN P C, 4875 PEARL EAST CIRCLE, SUITE 200, BOULDER, CO, 80301, US
Provisional Application: US 60869545, 2006-12-11
Filing Date: 2007-12-11
Publication Date: 2009-02-26
PDF: 20090055975
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