Estrogen agonist/antagonist metabolites

Document Number: RE039419

Abstract:

This invention relates to compounds that are mammalian metabolites of (−)-cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6,7,8-tetrahydro-naphthalene-2-ol. The compounds of the invention can be used as standards for analytical assays or as intermediates for the further chemical synthesis or biosynthesis of chemical entities. The invention also relates to pharmaceutical compositions for the treatment of disease and methods of treating disease.

Application Number: 10448751

Primary Class: 514424

Sub-Classes: 514428, 514567, 548543, 548576

Inventors: Wesley W. Day, Old Lyme, CT, US; Kim A. Johnson, East Haven, CT, US; Chandra A. Prakash, Gales Ferry, CT, US; James F. Eggler, Stonington, CT, US

Assignee: Pfizer Inc., New York, US

Provisional Application: US 60267198, 2000-04-07

Examiners: Fiona T. Powers (primary)

Filing Date: 2003-05-30

Publication Date: 2006-12-05

PDF: RE039419

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