Document Number: RE039815
Abstract:
A method for determining the ion channel activity of a substance comprises the steps of (i) expressing the substance as a heterologous protein in a host cell, and (ii) determining changes in permeability of the plasma membrane of the host cell induced by expression of the heterologous protein. A screening method for determining ion channel modulating activity of a test substance is also disclosed.
Application Number: 10800361
Primary Class: 435 5
Sub-Classes: 435 3, 435 5, 435 41, 435 693, 435325
Inventors: Angela Fay Dulhunty, Queanbeyan, AU; Graeme Barry Cox, Bawley Point, AU; Gary Dinneen Ewart, Hackett, AU
Assignee: The Australian National University, Acton, AU
Priority: AU: PO2581, 1996-09-27
PCT: WO PCT/AU97/00638, 1997-09-26
Examiners: Jeffrey Stucker (primary), Louise Humphrey (assistant)
Filing Date: 1997-09-26
Publication Date: 2007-09-04
PDF: RE039815
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