Document Number: RE039866
Abstract:
Modulation of the activity of the insulin receptor, enhancement of glucose uptake by cells, and other effects significant in the control and management of diabetes are accomplished using compounds of the formula
wherein
- each A is independently a proton-accepting substituent;
- each R is independently a noninterfering substituent;
- n is 0, 1, or 2; and
- each linker is independently an isostere of —NHCONH— or of —N═N— or of —NHCO—.
Compounds in the genus of Formula (1) can also be used for structure activity studies to identify features responsible for the relevant activities.
Application Number: 11167026
Primary Class: 514150
Sub-Classes: 514596, 514597, 514598, 514708, 514765, 514866, 534573, 534806, 534808
Inventors: Richard Sportsman, Encinitas, CA, US; Hugo O. Villar, La Jolla, CA, US; Lawrence M Kauvar, San Francisco, CA, US; Wayne R Spevak, Berkeley, CA, US
Assignee: Telik, Inc., San Francisco, US
Examiners: Shengjun Wang (primary)
Filing Date: 2005-06-23
Publication Date: 2007-10-02
PDF: RE039866
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