Document Number: 7374745
Abstract:
New ultrasound contrast agents that comprise microbubbles encapsulating a gas within a shell made from a blend of bipolar compounds having mixed carbon chain length. The compounds have hydrophobic groups selected from the group consisting of straight-chained alkyls, alkylethers, alkylthiolethers, alkyldisulfides, polyfluoroalkyls, and polyfluoroalkylethers having a carbon chain length greater than or equal to 16 and less than or equal to 32. The polar groups are connected to the hydrophobic groups by means of a linker. The polar head groups are selected from the group consisting of CO2-M+, SO3−M+, SO4−M+, PO3−M+, PO4−M+2, N(R)4+, a pyridinium or substituted pyridinium group, and a zwitterionic group; R is selected from the group consisting of —H, —CH3, alkyl, cycloalkyl, substituted cycloalkyls containing one or more heteroatoms, and benzyl and can be the same or different; and Z′ is a nonionic and M is a cation.
Application Number: 10798486
Primary Class: 424 952
Sub-Classes: 424 95
Inventors: Gary L. Cantrell, Troy, IL, US
Assignee: Mallinckrodt, Inc., St. Louis, US
Provisional Application: US 60103860, 1998-10-12
Examiners: Michael G Hartley (primary), Leah Schlientz (assistant)
Extension: 487
Filing Date: 2004-03-11
Publication Date: 2008-05-20
PDF: 7374745
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