CENTRAL ACTIONS OF ANGIOTENSIN II IN THE CONTROL OF FLUID BALANCE
Marie Lori
University Of Pennsylvaniacity: Philadelphia country: United States (us)
Grant 5R01HL091314-04 from National Heart, Lung, And Blood Institute
Keywords: Acetates; Address; Adrenal Cortex Hormones; Adrenal Glands; Aldosterone; analog; Angiotensin II; Angiotensin II Receptor; Animals; Area; Atherosclerosis; base; Behavior; Behavioral; Behavioral Mechanisms; Binding (Molecular Function); Biological Assay; Biological Models; Body Fluids; Brain; Brain region; Captopril; Cardiovascular Diseases; Cardiovascular Physiology; Cardiovascular system; Cell Culture Techniques; Cell physiology; Cells; Contrast Media; Corticosterone; Counseling; Coupled; CRH gene; Deoxycorticosterone; Desire for food; Development; Dexamethasone; Diuretics; Dose; Drug Combinations; EGF gene; Ensure; Epidermal Growth Factor Receptor; Equilibrium; Fluid Balance; Foundations; Functional disorder; Furosemide; Genomics; GTP-Binding Proteins; Heart failure; Histologic; Homeostasis; Hormones; Hydrolysis; Hypertension; hypertension treatment; hypocretin; Hypotension; Hypothalamic structure; Immunoblot Analysis; Immunoblotting; In Vitro; in vitro Model; in vivo; Ingestion; inhibitor/antagonist; Injection of therapeutic agent; Intake; interest; Lateral; Ligands; Link; Liquid substance; Literature; Losartan; MAPK1 gene; MAPK3 gene; Maps; Mediating; MEKs; Mitogen Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mitogens; Modeling; motivated behavior; neurochemistry; Organ; organum vasculosum of the lamina terminalis; Pathway interactions; Patients; peptide hormone; Peptides; Pharmaceutical Preparations; Phenotype; Phosphatidylinositols; Physiological; Process; protein activation; Proteins; Rat-1; Rattus; receptor; Receptor Signaling; Regulation; Renal function; Renin-Angiotensin System; Reporting; Research; research study; response; Role; salt intake; Sampling; Signal Pathway; Signal Transduction; Site; Sodium; Sodium Chloride; Steroids; Structure of area postrema; Subfornical Organ; Testing; Thirst; Time; Trans-Activation (Genetics); Water consumption; water drinking behavior
Relevance: The hormone angiotensin II is a focus of intense research because it has been strongly implicated in the development of cardiovascular disease. Of the many actions of this hormone within the body, angiotensin II is an important regulator of fluid balance by coordinating physiological actions, such as kidney and cardiovascular function, with the behaviors of water drinking and the ingestion of salt (sodium). Because the regulation of sodium balance in all animals is a key aspect of body fluid regulation, control of sodium intake is an important point of emphasis in the treatment of hypertension. While all hypertensive patients are counseled to restrict their sodium intake, many have great difficulty in complying. Thus, an understanding of this behavior has important ramifications with respect to the development of hypertension and cardiovascular disease
Project start date: 2008-12-16
Project end date: 2013-11-30
Budget start date: 1-DEC-2011
Budget end date: 30-NOV-2012
5R01HL091314-04 (2012): $350831
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